On February 13, 1968, Holy Cross High School was informed by the Archdiocese of San Antonio that all subsidies would end on May 31st, the final day of the school year. Second, it was believed that due to its location, Holy Cross High School could not support itself and it should close its doors. This decision was unacceptable to the parents, students, faculty, community leaders and alumni of Holy Cross High School. Their support and the dedication of Ms. Vikki Carr carried Holy Cross High School through these threatening times. It was soon resolved that Holy Cross High School would remain open under the sole supervision but not the ownership of the Brothers of Holy Cross. The financial strain at Holy Cross High School was not unique. At the same time, several nearby Catholic elementary schools were closing. In response, Holy Cross High School expanded to include grades seven and eight. Holy Cross was now a college preparatory middle and secondary school.
Subsequent years saw the Brothers busy with the educational and spiritual development of the increasing student body and the numerous financial requirements consistent with running a school. At the same time, the Brothers were driven by the realization that in the surrounding community, basic medical services were not available. The U. S. Department of Health and Human Services had the surrounding community classified as a physician shortage area. Discussion by students, faculty and alumni eventually led to the establishment of Holy Cross Family Medical Center in 1981. In 1985 the Medical Center expanded and located directly across from the campus of Holy Cross High School, a facility that remains in operation today.